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G| There are 35 entries in the glossary. |
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| Genetic Diseases | Diseases that occur because a mutation in the genetic material. |
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| Genetic Engineering | The selective, deliberate alteration of genes by technological means. |
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| Genetics | The scientific study of heredity: how particular qualities or traits are transmitted from parents to offspring. |
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| Genome Project | Research and technology development effort aimed at mapping and sequencing some or all of the genome human beings and other organisms. |
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| Genomic Library | A collection of clones made from a set of randomly generated overlapping DNA fragments representing the entire genome of an organism. |
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| Genomic Sequence | The order of the subunits, called bases, that makes up a particular fragment of DNA in a genome. DNA is a long molecule made up of four different kinds of bases, which are abbreviated A, C, T, and G. A DNA fragment that is 10 bases long might have a base sequence of, for example, ATCGTTCCTG. The particular sequence of bases encodes important information in an individual's genetic blueprint, and is unique for each individual (except identical twins).
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| Genotype | The genetic composition of an organism (including expressed and nonexpressed genes), which may not be readily apparent. |
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| Germicidal Lamps | Light sources that emit ultraviolet radiation at a wavelength of 254 nanometers. These lights are commonly found in biological safety cabinets and used to inactivate bacteria, viruses and fungi which are either airborne or on exposed surfaces. |
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| Germicide | An agent that destroys microorganisms, especially pathogenic microorganisms ("germs"). Sterilants, disinfectants, and antiseptics are germicides. |
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| Germplasm | The total genetic variability, represented by germ cells or seeds, available to a particular population of organisms. |
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| GMP Critical Parameter | A parameter that has a direct effect on product quality |
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| GMP Facility | A production facility or clinical trial materials pilot plant for the manufacture of pharmaceutical products. It includes the manufacturing space, the storage warehouse for raw and finished product, and support lab areas. A GMP facility operates under the guidelines established by the CFR (Code of Federal Regulations) Title 21, Parts 225 (Current Good Manufacturing for Medicated Feeds - Subpart B), and Part 226 (Current Good Manufacturing Practice for Type A Medicated Articles - Subpart B). |
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| Golgi Bodies | Very small particles composed of membrane aggregates and responsible for the secretion of certain enzymes and macromolecules. Golgi bodies are the deposition and packaging site for many excreted products. |
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| Good Engineering Practice (GEP) | A combination of standards, specifications, codes, regulatory and industrial guidelines as well as accepted engineering and design methods intended to design, construct, operate, and maintain pharmaceutical and/or biotechnology facilities taking into account not only regulatory compliance but also safety, economics, environmental protection and operability. Standards and specifications are provided by recognized sources such as established engineering and architectural contractors as well as pharmaceutical companies. Codes are provided by local, state, or federal jurisdictions and/or insurance companies. Guidelines are issued by professional societies, industrial organizations, or regulatory agencies. Engineering design methods have been established throughout the engineering educational system. |
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| Good Large Scale Practice Organism (GLSP | The National Institutes of Health (NIH) specifies physical containment levels and defines Biosafety Levels for Large Scale in their "Guidelines for Research Involving Recombinant DNA Molecules" - Appendix K - May 1999. Level of physical containment recommended for large-scale (more than 10 liters of culture) research or production involving viable, non-pathogenic, and non-toxigenic recombinant strains derived from host organisms that have an extended history of safe large scale use. Likewise, the GLSP level of physical containment is recommended for organisms that have a built-in environmental limitation that permits optimum growth in large-scale bioreactors, but limited survival if released to the environment. |
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Glossary V2.0 |
