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| There are 121 entries in the glossary. |
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| Advisory Alarm | An alarm indicating a drift of a monitored parameter toward an out-of-spec condition. It is advisory in that no GMP violation has occurred, and is used to advise corrective action before an action alarm can happen. |
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| Aerobe | An organism that can live and grow only in the presence of oxygen.
1. Facultative aerobe: one which normally thrives in the absence of oxygen, but which may acquire the faculty of living in the presence of oxygen.
2. Obligate aerobe: one that cannot live without air. |
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| Aerobia | The plural of aerobe. |
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| Aerobic | Living in air |
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| Aerobic Bacteria | Bacteria capable of growing in the presence of Oxygen |
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| Aerobion | see: Aerobe |
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| Aerosol | A product that is dispensed by a propellant from a metal can up to a maximum size of 33.8 fluid ounces (1000 mL) or a glass or plastic bottle up to a size of 4 fluid ounces (118.3 mL), other than a rim-vented container. |
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| Aerosol Photometer | Light-scattering mass concentration indicating instrument with a threshold sensitivity of at least 10 to the negative third power microgram per liter for 0.3µm diameter DOP (Dioctyl Phthalate) concentrations over a range of 10 to the fifth power times the threshold sensitivity. Photometers may include hand-held remote meter probes that can scan for airborne contaminants in HEPA filters, in penetrations around frames, seals and plenums, and in hoods and work stations. |
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| AES | see: Auger Electron Spectroscopy |
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| Agar | A complex mixture of polysaccharides obtained from marine red algae, used as an emulsion stabilizer in foods, as a sizing in fabrics, as a gelling agent and as a solid substrate or media for the laboratory culture of microorganisms. Agar melts at 100ºC and when cooled below 44ºC forms a stiff and transparent gel. Microorganisms are seeded and grown on the surface of the gel. |
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| Agarose | A highly purified form of agar. |
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| Agarose Gel Electrophoresis | A method used to separate, identify, and purify molecules of different molecular weight and/or structure. It is specifically applied to the separation of protein or DNA fragments where it is rapid, simple, and accurate, and the separated molecules can be visualized directly by staining with dyes. The electrophoretic migration rate of molecules through agarose gel is dependent on the following parameters:
1. Molecular size: molecules pass through the gel at rates that are inversely proportional to the log of their molecular weight.
2. Agarose concentration: a molecule of a given size migrates at different rates through gels containing different concentrations of agarose.
3. Molecular conformation: a molecule of the same molecular weight but of a different conformation will migrate at different rates. Generally, closed circular or globular forms will migrate faster than linear forms.
4. Electric current: at low voltages the rate of migration is proportional to the voltage, but as the voltage is increased the rate of migration of high molecular weight fragments is increased differentially. |
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| Agene | Nitrogen Trichloride (NCl3). |
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| Agglomerate | Suspended solids clustered together to form larger clumps or masses that are easier to remove by filtration or settling. |
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| Agglutination | The sticking together of insoluble antigens such as bacteria, viruses or erythrocytes by a particular antibody. Agglutination assays are used to type human blood before a transfusion |
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| AHF (Antihemophilic Factor) | In the clotting of blood it is also known as Factor VIII. |
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| Air Change Rate | The number of times the total air volume of a defined space is replaced in a given unit of time. This is computed by dividing the total volume of the subject space (in cubic feet) into the total volume of air exhausted from (or supplied to) the space per unit of time. |
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| Air Cleaners | Filtration systems that may be freestanding or installed in a ceiling or wall to remove contaminants such as bacteria, viruses, and dust from the air. Air cleaners may incorporate HEPA filters. |
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| Air Velocity Meters/Monitors | Meters to measure and indicate the force and speed of airflow. Meters may use a variety of probes for measuring near HEPA filters and at right angles. Monitors check and record air velocity. |
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| Air-Lift Bioreactor | A reactor in which the source of agitation is air sparged upwards through a draft tube - most widely used for cell culture applications and monoclonal antibody production. |
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Glossary V2.0 |
