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MedWorm: Complementary Medicine
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  • Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells.
    In this study, we sought to examine the effect of Andro on autophagy, and to evaluate whether such effect is relevant to the sensitization effect of Andro on apoptosis induced by DNA damage agents in cancer cells. First, we found that Andro is able to significantly enhance autophagic markers in various cancer cell lines, including GFP-LC3 puncta and LC3-II level. Interestingly, Andro treatment also led to marked increase of p62 protein level and addition of chloroquine (CQ) failed to further enhance either LC3-II or p62 level, indicating that Andro is likely to suppress autophagic flux at the maturation and degradation stage. Next, we provided evidence that Andro inhibits autophagosome maturation not by affecting the lysosomal function, but by impairing autophagosome-lysosome fusion. Lastl...

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  • Soy Supplements May Not Shield Against Breast Cancer
    Study suggests no reduction in tumor risk, but one expert says more research may be needed (Source: The Doctors Lounge - Oncology)

  • Big Biotech and Big Pharma: no place to hide?
    The importance of continued pressure amid European corporate pullouts (Source: Alliance for Natural Health)

  • NCCAM's Advisory Council Welcomes Six New Members
    The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The council serves as the principal advisory body to NCCAM, the lead federal agency for research on complementary medicine, and a component of the National Institutes of Health. (Source: NCCAM Featured Content)

  • Australia attempts to enact scientific dictatorship at universities by banishing alternative medicine courses
    Self-proclaimed advocates of "science-based" medicine are hard at work trying to eliminate government funding for any form of medical education or treatment that is not conventional in nature. The Sydney Morning Herald reports that a new lobbying group of 400 "doctors... (Source: NaturalNews.com)

  • In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract
    Conclusion: D. alata barks extract is neither mutagenic by the Ames test nor toxic in the pregnancy of rats, with no physical-neurobehavioral consequences on the rat offsprings development. (Source: BMC Complementary and Alternative Medicine)

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  • A Comparison of Self-Reported Analgesic Use and Detection of Urinary Ibuprofen and Acetaminophen Metabolites by Means of Metabonomics: The INTERMAP Study
    Information on dietary supplements, medications, and other xenobiotics in epidemiologic surveys is usually obtained from questionnaires and is subject to recall and reporting biases. The authors used metabolite data obtained from hydrogen-1 (or proton) nuclear magnetic resonance (1H NMR) analysis of human urine specimens from the International Study of Macro-/Micro-Nutrients and Blood Pressure (INTERMAP Study) to validate self-reported analgesic use. Metabolic profiling of two 24-hour urine specimens per individual was carried out for 4,630 participants aged 40–59 years from 17 population samples in Japan, China, the United Kingdom, and the United States (data collection, 1996–1999). 1H NMR-detected acetaminophen and ibuprofen use was low (~4%) among East Asian population sampl...

  • Army Studies Workout Supplements After 2 Deaths
    The military has removed dietary supplements containing the ingredient dimethylamylamine from stores on its bases, though the products are widely available elsewhere in the country. (Source: NYT Health)

  • Breakthrough in Alzheimer?s and Dementia?
    Coconut oil, once thought to be harmful due to elevating cholesterol levels, actually has numerous positive influences on human health. (Source: ChiroACCESS: Tools for Better Patient Care)

  • Herbal medicine ?unjustified? for osteoarthritis
    There is little conclusive evidence to justify the use of herbal medicines for the relief of symptoms in people with osteoarthritis, concludes a review in the Drug and Therapeutics Bulletin. (Source: MedWire News - Bone Health)

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